Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942319 | 0.95 | TEAD3 (0.56) | LTA4HTMEM97SIGMAR1TEAD3KDM4E | |
| SCHEMBL6947336 | 0.94 | LTA4H (0.55) | LTA4HTMEM97SIGMAR1TEAD3MEN1 | |
| SCHEMBL8109363 | 0.94 | LTA4H (0.55) | LTA4HTMEM97SIGMAR1TEAD3MEN1 | |
| SCHEMBL8115844 | 0.93 | LTA4H (0.54) | LTA4HTMEM97SIGMAR1TEAD3MEN1 | |
| SCHEMBL6947688 | 0.93 | LTA4H (0.54) | LTA4HTMEM97SIGMAR1TEAD3MEN1 | |
| SCHEMBL6943888 | 0.93 | LTA4H (0.54) | LTA4HTMEM97SIGMAR1TEAD3MEN1 | |
| SCHEMBL4318812 | 0.91 | LTA4H (0.65) | LTA4HTMEM97SIGMAR1TEAD3MEN1 | |
| SCHEMBL19557301 | 0.85 | LTA4H (0.75) | LTA4HSIGMAR1TEAD3MEN1GAA | |
| SCHEMBL26981197 | 0.85 | LTA4H (0.75) | LTA4HSIGMAR1TEAD3MEN1GAA | |
| SCHEMBL6855553 | 0.84 | TEAD3 (0.58) | LTA4HTMEM97SIGMAR1TEAD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389373-B1 | DERIVATIVES OF N2-(3-PYRIDYL OR PHENYL)-N4-(4-PIPERIDYL)-2,4-PYRIMIDINEDIAMINE USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE OR PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS INC (US) | 2017-05-17 | — | — | EP | disclosed |
| WO-2015177326-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-11-26 | — | — | WO | disclosed |