SCHEMBL1728491

SCHEMBL1728491

CN(C)CCOc1ccc(-n2ccn(-c3ccc(Cc4ccncc4)cc3)c2=O)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 3/20 0.52
CYP2D6 P10635 4/20 0.52
CYP2C9 P11712 4/20 0.52
CYP1A2 P05177 3/20 0.52
CYP2C19 P33261 3/20 0.52
MCHR1 Q99705 2/20 0.50
HRH3 Q9Y5N1 3/20 0.46
CYP3A4 P08684 3/20 0.45
KEAP1 Q14145 1/20 0.45
NFE2L2 Q16236 1/20 0.45
MAPK14 Q16539 1/20 0.44
ADORA3 P0DMS8 1/20 0.40
ADORA2A P29274 1/20 0.40
ADORA2B P29275 1/20 0.40
ADORA1 P30542 1/20 0.40
KCNH2 Q12809 1/20 0.40
CHRNB2 P17787 1/20 0.40
CHRNA4 P43681 1/20 0.40
FGFR1 P11362 1/20 0.40
SRC P12931 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1728658 0.88 LTA4H (0.70) LTA4HCYP2D6CYP2C9CYP1A2CYP2C19
SCHEMBL6081522 0.81 ALDH1A1 (0.55) LTA4HCYP2D6CYP2C9CYP1A2CYP2C19
SCHEMBL6080985 0.81 MCHR1 (0.54) LTA4HCYP2D6CYP2C9CYP1A2CYP2C19
SCHEMBL6081903 0.81 MCHR1 (0.54) LTA4HCYP2D6CYP2C9CYP1A2CYP2C19
SCHEMBL6081331 0.80 MCHR1 (0.53) LTA4HCYP2D6CYP2C9CYP1A2CYP2C19
SCHEMBL1728477 0.80 MCHR1 (0.56) CYP2D6CYP2C9CYP1A2CYP2C19MCHR1
SCHEMBL1728527 0.80 MCHR1 (0.51) LTA4HCYP2D6CYP2C9CYP1A2CYP2C19
SCHEMBL1728621 0.80 MCHR1 (0.63) LTA4HCYP2D6CYP2C9CYP1A2CYP2C19
SCHEMBL6081922 0.80 HRH3 (0.54) LTA4HCYP2D6CYP2C9CYP1A2CYP2C19
SCHEMBL6081632 0.79 MCHR1 (0.52) LTA4HCYP2D6CYP2C9CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1551810-B1 DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT SANOFI AVENTIS DEUTSCHLAND (DE) 2011-11-30 EP disclosed
US-7141561-B2 Substituted diaryl heterocycles, process for their preparation and their use as medicaments SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2006-11-28 US disclosed