Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 11/20 | 0.70 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728493 | 0.90 | MCHR1 (0.78) | LTA4HMCHR1KCNH2FGFR1SRC | |
| SCHEMBL1728491 | 0.88 | LTA4H (0.52) | LTA4HMCHR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6082151 | 0.87 | MCHR1 (0.60) | LTA4HMCHR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1728669 | 0.87 | LTA4H (0.68) | LTA4HMCHR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1727382 | 0.84 | MCHR1 (0.57) | LTA4HMCHR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13588339 | 0.84 | LTA4H (1.00) | LTA4HCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6081903 | 0.83 | MCHR1 (0.54) | LTA4HMCHR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6080985 | 0.83 | MCHR1 (0.54) | LTA4HMCHR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6081522 | 0.83 | ALDH1A1 (0.55) | LTA4HMCHR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6081331 | 0.82 | MCHR1 (0.53) | LTA4HMCHR1CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |