Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 3/20 | 0.74 |
| ▸ | FEN1 | P39748 | 3/20 | 0.74 |
| ▸ | MMP1 | P03956 | 2/20 | 0.63 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.58 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944973 | 0.85 | ERCC5 (1.00) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL29169327 | 0.85 | ERCC5 (0.70) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL24209329 | 0.85 | ERCC5 (0.70) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL9814634 | 0.84 | MMP1 (0.77) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL1728532 | 0.84 | ERCC5 (0.68) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| Diphenylether SCHEMBL27775292 | 0.83 | LTA4H (0.60) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL4437033 | 0.83 | MMP1 (0.71) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL28547033 | 0.82 | ERCC5 (0.66) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL8341053 | 0.82 | ERCC5 (0.66) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL11832773 | 0.82 | ERCC5 (0.66) | ERCC5FEN1MMP1PARP10SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111499572-B | Preparation method of intermediate of roxasistat | 安徽省庆云医药股份有限公司 | 2022-04-01 | — | — | CN | claimed |
| CN-111499572-A | Preparation method of intermediate of roxasistat | 安徽省庆云医药股份有限公司 | 2020-08-07 | — | — | CN | claimed |
| CN-117105862-A | Preparation method of roflumilast and intermediate thereof | 北京福元医药股份有限公司 | 2023-11-24 | — | — | CN | disclosed |
| CN-117105862-A | Preparation method of roflumilast and intermediate thereof | 北京福元医药股份有限公司 | 2023-11-24 | — | — | CN | disclosed |
| CN-111499572-B | Preparation method of intermediate of roxasistat | 安徽省庆云医药股份有限公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-111499572-B | Preparation method of intermediate of roxasistat | 安徽省庆云医药股份有限公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-111499572-A | Preparation method of intermediate of roxasistat | 安徽省庆云医药股份有限公司 | 2020-08-07 | — | — | CN | disclosed |
| CN-111499572-A | Preparation method of intermediate of roxasistat | 安徽省庆云医药股份有限公司 | 2020-08-07 | — | — | CN | disclosed |
| US-8865751-B2 | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-10-21 | — | — | US | disclosed |
| US-20130090479-A1 | THIAZOLES, IMIDAZOLES, AND PYRAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-04-11 | — | — | US | disclosed |
| US-8236832-B2 | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INC. (US) | 2012-08-07 | — | — | US | disclosed |
| US-5128396-A | Corrosion inhibiting primers on metallic substrates | CIBA-GEIGY CORPORATION (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0412933-A1 | Coating compositions | CIBA-GEIGY AG (CH) | 1991-02-13 | — | — | EP | disclosed |
| EP-0164590-B1 | DERIVATIVES OF 4-(3'-TRIFLUOROMETHYLPHENOXY)-BENZOYLACETIC ACID | CIBA-GEIGY AG (CH) | 1988-08-31 | — | — | EP | disclosed |
| EP-0069055-B1 | DIHYDROPYRONES, PROCESS FOR THEIR PREPARATION AND HERBICIDAL AGENT CONTAINING THESE DIHYDROPYRONES AS ACTIVE INGREDIENTS | CIBA-GEIGY AG (CH) | 1986-12-17 | — | — | EP | disclosed |
| EP-0164590-A1 | Derivatives of 4-(3'-trifluoromethylphenoxy)-benzoylacetic acid | CIBA-GEIGY AG (CH) | 1985-12-18 | — | — | EP | disclosed |
| US-4460400-A | HERBICIDES | CIBA-GEIGY CORPORATION (US) | 1984-07-17 | — | — | US | disclosed |
| EP-0069055-A2 | Dihydropyrones, process for their preparation and herbicidal agent containing these dihydropyrones as active ingredients | CIBA-GEIGY AG (CH) | 1983-01-05 | — | — | EP | disclosed |
| US-3993670-A | OPTICAL BRIGHTENERS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-11-23 | — | — | US | disclosed |
| US-3971731-A | OPTICAL BRIGHTENER, UV ABSORBER | BAYER AKTIENGESELLSCHAFT (DT) | 1976-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130090479-A1 | THIAZOLES, IMIDAZOLES, AND PYRAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K5, MAP3K1, MAP3K20 | ERCC5 3188/4885FEN1 3152/4885MMP1 4335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.