Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 7/20 | 1.00 |
| ▸ | FEN1 | P39748 | 7/20 | 1.00 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.69 |
| ▸ | HAO1 | Q9UJM8 | 3/20 | 0.66 |
| ▸ | MMP1 | P03956 | 1/20 | 0.59 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728534 | 0.85 | ERCC5 (0.74) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL11714725 | 0.83 | ERCC5 (0.71) | ERCC5FEN1PTPN1MMP1PARP10 | |
| SCHEMBL1109671 | 0.82 | ERCC5 (1.00) | ERCC5FEN1PTPN1HAO1KMT2A | |
| SCHEMBL24209329 | 0.82 | ERCC5 (0.70) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL29169327 | 0.82 | ERCC5 (0.70) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL19545100 | 0.81 | ERCC5 (0.68) | ERCC5FEN1MMP1PARP10POLB | |
| SCHEMBL9814634 | 0.81 | MMP1 (0.77) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL1728532 | 0.81 | ERCC5 (0.68) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL30364011 | 0.81 | ERCC5 (0.95) | ERCC5FEN1PTPN1HAO1KMT2A | |
| SCHEMBL27835156 | 0.81 | ERCC5 (0.95) | ERCC5FEN1PTPN1HAO1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | claimed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |