Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728669 | 0.88 | LTA4H (0.68) | LTA4HMCHR1KCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL1728748 | 0.85 | MCHR1 (0.66) | LTA4HMCHR1KCNH2ALDH1A1MEN1 | |
| SCHEMBL6081348 | 0.83 | LTA4H (0.51) | LTA4HMCHR1KCNH2SMN1; SMN2 | |
| SCHEMBL1728135 | 0.83 | LTA4H (0.51) | LTA4HMCHR1KCNH2 | |
| SCHEMBL1728610 | 0.81 | KCNH2 (0.57) | LTA4HMCHR1KCNH2 | |
| SCHEMBL1728571 | 0.81 | LSS (0.41) | MCHR1KCNH2 | |
| SCHEMBL1729526 | 0.80 | KDM4E (0.46) | LTA4HMCHR1KCNH2ALDH1A1 | |
| SCHEMBL12744959 | 0.79 | LTA4H (0.58) | LTA4HKCNH2ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1727501 | 0.78 | LTA4H (0.45) | LTA4HMCHR1KCNH2 | |
| SCHEMBL1728761 | 0.78 | LTA4H (0.66) | LTA4HMCHR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |