Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | NOS2 | P35228 | 6/20 | 0.57 |
| ▸ | NOS3 | P29474 | 5/20 | 0.57 |
| ▸ | NOS1 | P29475 | 5/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22878388 | 0.89 | SIGMAR1 (0.49) | KDM4EALDH1A1NOS2NOS3NOS1 | |
| SCHEMBL17284490 | 0.87 | SIGMAR1 (0.48) | KDM4EALDH1A1NOS2NOS3NOS1 | |
| SCHEMBL17282019 | 0.85 | SIGMAR1 (0.46) | KDM4EALDH1A1NOS2NOS3NOS1 | |
| SCHEMBL18716730 | 0.84 | KDM4E (0.60) | KDM4EALDH1A1NOS2NOS3NOS1 | |
| SCHEMBL17286021 | 0.82 | NOS2 (0.59) | KDM4EALDH1A1NOS2NOS3NOS1 | |
| SCHEMBL8442356 | 0.82 | KDM4E (0.68) | KDM4EALDH1A1NOS2NOS3NOS1 | |
| SCHEMBL17285891 | 0.81 | ALDH1A1 (0.56) | KDM4EALDH1A1NOS2NOS3NOS1 | |
| SCHEMBL17285895 | 0.78 | NOS2 (0.59) | KDM4EALDH1A1NOS2NOS3NOS1 | |
| SCHEMBL17285893 | 0.77 | SLC6A2 (0.61) | KDM4EALDH1A1NOS2NOS3NOS1 | |
| SCHEMBL20871938 | 0.77 | KDM4E (0.62) | KDM4EALDH1A1NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170145020-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS,COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-05-25 | — | — | US | disclosed |
| US-9604984-B2 | 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2017-03-28 | — | — | US | disclosed |
| US-20160237086-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS,COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2016-08-18 | — | — | US | disclosed |
| US-9346815-B2 | 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2016-05-24 | — | — | US | disclosed |
| US-20150336962-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2015-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336962-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | ABL1, JAK2, FLT3 | KDM4E 708/4885ALDH1A1 729/4885NOS2 2771/4885 |
| US-20160237086-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS,COMPOSITIONS AND METHODS OF USE THEREOF | ABL1, JAK2, FLT3 | KDM4E 708/4885ALDH1A1 729/4885NOS2 2771/4885 |
| US-20170145020-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS,COMPOSITIONS AND METHODS OF USE THEREOF | ABL1, JAK2, FLT3 | KDM4E 708/4885ALDH1A1 729/4885NOS2 2771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.