Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17288081 | 1.00 | EZH2 (0.73) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL20749695 | 0.94 | EZH2 (0.82) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL15825066 | 0.94 | EZH2 (0.82) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL15825064 | 0.94 | EZH2 (0.82) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL17288085 | 0.92 | EZH2 (0.62) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL15825348 | 0.92 | EZH2 (0.62) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL15826616 | 0.90 | EZH2 (0.72) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL15826615 | 0.90 | EZH2 (0.72) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL15838998 | 0.87 | EZH2 (0.80) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL20749747 | 0.87 | EZH2 (0.80) | EZH2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935214-B1 | 1,4-PYRIDONE COMPOUNDS | EPIZYME INC (US) | 2019-02-20 | — | — | EP | disclosed |
| EP-2935214-B1 | 1,4-PYRIDONE COMPOUNDS | EPIZYME INC (US) | 2019-02-20 | — | — | EP | disclosed |
| US-20150344427-A1 | 1,4-PYRIDONE COMPOUNDS | Epizyme, Inc. (US) | 2015-12-03 | — | — | US | disclosed |
| US-20150344427-A1 | 1,4-PYRIDONE COMPOUNDS | Epizyme, Inc. (US) | 2015-12-03 | — | — | US | disclosed |
| US-20150344427-A1 | 1,4-PYRIDONE COMPOUNDS | Epizyme, Inc. (US) | 2015-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344427-A1 | 1,4-PYRIDONE COMPOUNDS | PDXK, PNPO, PLPBP | EZH2 3465/4885CYP2D6 165/4885CYP2C19 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.