Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 7/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1730128 | 0.86 | HTR3A (0.43) | AKR1C3HTR3ADRD3DRD2CNR2 | |
| SCHEMBL1729040 | 0.85 | HCAR2 (0.46) | HTR3ADPP4DPP8DPP9DPP7 | |
| SCHEMBL1730251 | 0.83 | DPP4 (0.42) | HTR3ADPP4DPP8DPP9DPP7 | |
| SCHEMBL1727957 | 0.82 | KDM4E (0.45) | HTR3AHTR2CHTR1ADPP4DPP8 | |
| SCHEMBL1727576 | 0.80 | ABL1 (0.35) | CHRM4DPP4DPP8DPP9DPP7 | |
| SCHEMBL1729122 | 0.78 | AKT1 (0.44) | DRD3DRD2HTR2AHTR2CHTR1A | |
| SCHEMBL1730013 | 0.78 | MAPK1 (0.48) | DPP4 | |
| SCHEMBL1727608 | 0.78 | LMNA (0.50) | — | |
| SCHEMBL1729389 | 0.78 | DPP4 (0.43) | DRD3DRD2HTR2CDPP4DPP7 | |
| SCHEMBL1727936 | 0.78 | MAPT (0.48) | HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633735-B1 | DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI SA (FR) | 2011-11-30 | — | — | EP | claimed |