Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 11/20 | 0.39 |
| ▸ | KDM6B | O15054 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CDC25B | P30305 | 1/20 | 0.32 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17294252 | 0.83 | KDM4C (0.53) | KDM4CKDM6BALDH1A1KDM4EKDM4D | |
| SCHEMBL16344094 | 0.81 | KDM4C (0.40) | KDM4CKDM6BALDH1A1KDM4EKDM4D | |
| SCHEMBL16094232 | 0.81 | TDP1 (0.50) | KDM4CKDM6BALDH1A1KDM4EKDM4D | |
| SCHEMBL2265522 | 0.76 | KDM4C (0.47) | KDM4CKDM6BALDH1A1KDM4EKDM4D | |
| SCHEMBL724581 | 0.75 | ALDH1A1 (0.52) | KDM4CKDM6BALDH1A1KDM4EKDM4D | |
| SCHEMBL22810576 | 0.72 | P2RX1 (0.44) | KDM4CKDM6BALDH1A1KDM4EKDM4D | |
| SCHEMBL465753 | 0.72 | ALDH1A1 (0.54) | ALDH1A1TDP1MAPTKMT2AGAA | |
| SCHEMBL1027774 | 0.72 | GAA (0.45) | KDM4CKDM6BALDH1A1KDM4EKDM4D | |
| SCHEMBL3932429 | 0.72 | KDM4C (0.48) | KDM4CKDM6BALDH1A1KDM4EKDM4D | |
| SCHEMBL2579028 | 0.71 | ALDH1A1 (0.52) | KDM4CKDM6BALDH1A1KDM4EKDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148975-A1 | NOVEL COMPOUNDS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015180612-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-12-03 | — | — | WO | disclosed |