Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM6B | O15054 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4A | O75164 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459640 | 0.82 | KDM4E (0.62) | KDM4CALDH1A1KDM4ETDP1L3MBTL1 | |
| SCHEMBL22810576 | 0.82 | P2RX1 (0.44) | KDM4CALDH1A1KDM6BKDM4EKDM4D | |
| SCHEMBL11590329 | 0.82 | TDP1 (0.42) | KDM4CALDH1A1KDM6BKDM4EKDM4D | |
| SCHEMBL587010 | 0.82 | ROCK2 (0.58) | KDM4CALDH1A1KDM6BKDM4EKDM4D | |
| SCHEMBL1027774 | 0.82 | GAA (0.45) | KDM4CALDH1A1KDM6BKDM4EKDM4D | |
| SCHEMBL30465597 | 0.82 | ROCK2 (0.58) | KDM4CALDH1A1KDM6BKDM4EKDM4D | |
| Hydrochloric Acid SCHEMBL10480638 | 0.81 | KDM4E (0.60) | KDM4CALDH1A1KDM4ETDP1L3MBTL1 | |
| SCHEMBL724581 | 0.80 | ALDH1A1 (0.52) | KDM4CALDH1A1KDM6BKDM4EKDM4D | |
| Hydrochloric Acid SCHEMBL2841145 | 0.80 | GAA (0.43) | KDM4CALDH1A1KDM6BKDM4EKDM4D | |
| Hydrochloric Acid SCHEMBL2432397 | 0.80 | ROCK2 (0.56) | KDM4CALDH1A1KDM6BKDM4EKDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651917-A1 | DIMERIC IAP INHIBITORS | Novartis AG (CH) | 2013-10-23 | — | — | EP | disclosed |
| US-20130266590-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2013-10-10 | — | — | US | disclosed |
| US-8445440-B2 | Dimeric IAP inhibitors | NOVARTIS AG (CH) | 2013-05-21 | — | — | US | disclosed |
| EP-2539333-A1 | DIMERIC IAP INHIBITORS | Novartis AG (CH) | 2013-01-02 | — | — | EP | disclosed |
| WO-2012080260-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2012-06-21 | — | — | WO | disclosed |
| WO-2011104266-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2011-09-01 | — | — | WO | disclosed |
| US-20110206690-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2011-08-25 | — | — | US | disclosed |
| US-4739062-A | REACTING AN AROMATIC COMPOUND WITH DICARBOXYLIC ACID COMPOUND USING METAL HALIDE CATALYST | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1988-04-19 | — | — | US | disclosed |
| US-3944544-A | BACTERICIDE | E. R. SQUIBB & SONS, INC. (US) | 1976-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130266590-A1 | DIMERIC IAP INHIBITORS | XIAP, BIRC5, BIRC2 | KDM4C 3832/4885ALDH1A1 4312/4885KDM6B 2616/4885 |
| US-20110206690-A1 | DIMERIC IAP INHIBITORS | XIAP, BIRC5, BIRC2 | KDM4C 4210/4885ALDH1A1 4127/4885KDM6B 2755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.