Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4816775 | 0.85 | SIRT3 (0.55) | TDP1SIRT3KDM4EALDH1A1KDM4C | |
| SCHEMBL17294252 | 0.83 | KDM4C (0.53) | TDP1KDM4EALDH1A1KDM4CMEN1 | |
| SCHEMBL16344094 | 0.81 | KDM4C (0.40) | TDP1SIRT3KDM4EALDH1A1KDM4C | |
| SCHEMBL17294374 | 0.81 | KDM4C (0.39) | TDP1SIRT3KDM4EALDH1A1KDM4C | |
| SCHEMBL16094860 | 0.81 | TDP1 (0.55) | TDP1SIRT3KDM4EALDH1A1KDM4C | |
| SCHEMBL1687197 | 0.80 | TDP1 (0.67) | TDP1SIRT3KDM4EALDH1A1KDM4C | |
| SCHEMBL1330970 | 0.80 | TDP1 (0.67) | TDP1SIRT3KDM4EALDH1A1KDM4C | |
| SCHEMBL30298673 | 0.75 | TDP1 (0.55) | TDP1SIRT3KDM4EALDH1A1KDM4C | |
| SCHEMBL2618803 | 0.75 | TDP1 (0.55) | TDP1SIRT3KDM4EALDH1A1KDM4C | |
| SCHEMBL11870062 | 0.75 | KDM4C (0.62) | TDP1SIRT3KDM4EALDH1A1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970216-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151616-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2014-09-25 | — | — | WO | disclosed |