SCHEMBL1729474

SCHEMBL1729474

CC1CCCN1CCOc1ccc(-n2ccn(-c3ccc(Oc4ccccc4)cc3)c2=O)cc1

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 16/20 0.57
KCNH2 Q12809 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6081377 0.87 LTA4H (0.44) HRH3KCNH2
SCHEMBL6081517 0.86 LTA4H (0.45) HRH3KCNH2
SCHEMBL6081905 0.86 MCHR1 (0.48) HRH3KCNH2
SCHEMBL6081914 0.86 MCHR1 (0.48) HRH3KCNH2
SCHEMBL1727559 0.85 HRH3 (0.51) HRH3KCNH2
SCHEMBL6081329 0.85 MCHR1 (0.49) HRH3KCNH2
SCHEMBL1727398 0.85 NPC1 (0.49) HRH3KCNH2
SCHEMBL1729757 0.84 LTA4H (0.53) HRH3KCNH2
SCHEMBL1728441 0.84 HRH3 (0.41) HRH3KCNH2
SCHEMBL6081581 0.83 LTA4H (0.50) HRH3KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1551810-B1 DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT SANOFI AVENTIS DEUTSCHLAND (DE) 2011-11-30 EP disclosed