Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 7/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | LTA4H | P09960 | 6/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081488 | 0.90 | MCHR1 (0.48) | MCHR1KCNH2LTA4HFFAR1MCHR2 | |
| SCHEMBL6081914 | 0.87 | MCHR1 (0.48) | MCHR1KCNH2LTA4HFFAR1MCHR2 | |
| SCHEMBL6081905 | 0.87 | MCHR1 (0.48) | MCHR1KCNH2LTA4HFFAR1MCHR2 | |
| SCHEMBL1727398 | 0.86 | NPC1 (0.49) | MCHR1KCNH2LTA4HMCHR2HRH3 | |
| SCHEMBL1729474 | 0.85 | HRH3 (0.57) | KCNH2HRH3 | |
| SCHEMBL6081517 | 0.84 | LTA4H (0.45) | MCHR1KCNH2LTA4HFFAR1MCHR2 | |
| SCHEMBL6081377 | 0.82 | LTA4H (0.44) | MCHR1KCNH2LTA4HMCHR2HRH3 | |
| SCHEMBL6081709 | 0.82 | TMEM97 (0.69) | MCHR1KCNH2LTA4HTMEM97SIGMAR1 | |
| SCHEMBL5888840 | 0.80 | TMEM97 (0.57) | LTA4HTMEM97SIGMAR1 | |
| SCHEMBL6081884 | 0.80 | TMEM97 (0.60) | MCHR1KCNH2LTA4HTMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |