Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.43 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729474 | 0.87 | HRH3 (0.57) | HRH3KCNH2 | |
| SCHEMBL6081517 | 0.84 | LTA4H (0.45) | LTA4HHRH3MCHR1KCNH2MCHR2 | |
| SCHEMBL6081905 | 0.83 | MCHR1 (0.48) | LTA4HHRH3MCHR1KCNH2MCHR2 | |
| SCHEMBL6081914 | 0.83 | MCHR1 (0.48) | LTA4HHRH3MCHR1KCNH2MCHR2 | |
| SCHEMBL1727398 | 0.82 | NPC1 (0.49) | LTA4HHRH3MCHR1KCNH2MCHR2 | |
| SCHEMBL6081329 | 0.82 | MCHR1 (0.49) | LTA4HHRH3MCHR1KCNH2MCHR2 | |
| SCHEMBL1727509 | 0.81 | LTA4H (0.42) | LTA4HHRH3MCHR1KCNH2MCHR2 | |
| SCHEMBL6081581 | 0.81 | LTA4H (0.50) | LTA4HHRH3MCHR1KCNH2MCHR2 | |
| SCHEMBL6081488 | 0.80 | MCHR1 (0.48) | LTA4HHRH3MCHR1KCNH2MCHR2 | |
| SCHEMBL6081396 | 0.80 | LTA4H (0.54) | LTA4HHRH3MCHR1KCNH2PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |