Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 16/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 16/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17295248 | 1.00 | S1PR1 (0.45) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295641 | 0.92 | S1PR1 (0.48) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295639 | 0.92 | S1PR1 (0.48) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295529 | 0.89 | S1PR1 (0.45) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295527 | 0.89 | S1PR1 (0.45) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295426 | 0.86 | FAAH (0.44) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295428 | 0.86 | FAAH (0.44) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295290 | 0.85 | S1PR1 (0.50) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295292 | 0.85 | S1PR1 (0.50) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295520 | 0.84 | ALDH1A1 (0.49) | S1PR1S1PR3ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148990-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181337-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2015-12-03 | — | — | WO | disclosed |