Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL17295754 | 0.93 | RAB9A (0.34) | RAB9AMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL17295787 | 0.90 | MEN1 (0.36) | RAB9AMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL19874122 | 0.89 | RAB9A (0.36) | RAB9AMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL17295745 | 0.88 | RAB9A (0.39) | RAB9ASMN1; SMN2NPC1ALDH1A1FPR2 | |
| SCHEMBL19874136 | 0.85 | RAB9A (0.35) | RAB9AMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL19874123 | 0.85 | RAB9A (0.36) | RAB9AMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL19874121 | 0.85 | RAB9A (0.36) | RAB9AMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL19874254 | 0.85 | RAB9A (0.38) | RAB9AMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL19874176 | 0.84 | RAB9A (0.34) | RAB9AMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL19874334 | 0.84 | RAB9A (0.35) | RAB9AMAPTMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180317-B1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME (US) | 2021-04-14 | — | — | EP | disclosed |
| EP-3500556-A1 | PYRIDINE-1-OXIDE DERIVATIVES AND THEIR USE AS FACTOR XIA INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2019-06-26 | — | — | EP | disclosed |
| US-10143681-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-12-04 | — | — | US | disclosed |
| WO-2018039094-A1 | PYRIDINE-1-OXIDE DERIVATIVES AND THEIR USE AS FACTOR XIA INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-03-01 | — | — | WO | disclosed |
| US-20180050022-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP (US) | 2018-02-22 | — | — | US | disclosed |
| US-20180050022-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP (US) | 2018-02-22 | — | — | US | disclosed |
| US-20180050022-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP (US) | 2018-02-22 | — | — | US | disclosed |
| US-9868727-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-01-16 | — | — | US | disclosed |
| US-9783530-B2 | Factor Xla inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-10-10 | — | — | US | disclosed |
| US-9783530-B2 | Factor Xla inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-10-10 | — | — | US | disclosed |
| US-9783530-B2 | Factor Xla inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-10-10 | — | — | US | disclosed |
| US-20170210732-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-07-27 | — | — | US | disclosed |
| US-20170197953-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-07-13 | — | — | US | disclosed |
| US-20170197953-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-07-13 | — | — | US | disclosed |
| US-20170197953-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-07-13 | — | — | US | disclosed |
| EP-3148542-A1 | FACTOR XIA INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-04-05 | — | — | EP | disclosed |
| CN-106413710-A | Factor xia inhibitors | 默沙东公司 | 2017-02-15 | — | — | CN | disclosed |
| WO-2015183709-A1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-12-03 | — | — | WO | disclosed |
| WO-2015183709-A1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10143681-B2 | Factor XIa inhibitors | F11, F2, TFPI | RAB9A 1808/4885MAPT 3908/4885MEN1 864/4885 |
| US-20170197953-A1 | FACTOR XIa INHIBITORS | F11, TFPI, F2 | RAB9A 1862/4885MAPT 3957/4885MEN1 891/4885 |
| US-20170210732-A1 | Factor XIa Inhibitors | F11, SERPINC1, TFPI | RAB9A 1961/4885MAPT 3611/4885MEN1 641/4885 |
| US-20180050022-A1 | FACTOR XIa INHIBITORS | F11, F2, TFPI | RAB9A 1808/4885MAPT 3908/4885MEN1 864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.