Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | KLK7 | P49862 | 1/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12698771 | 0.84 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTRAB9AHPGDKLK7 | |
| SCHEMBL3054687 | 0.83 | KCNH2 (0.63) | SMN1; SMN2LMNAMAPK1MAPTHPGD | |
| SCHEMBL3059881 | 0.82 | KCNH2 (0.61) | SMN1; SMN2MAPTRAB9AHPGDNR1H4 | |
| SCHEMBL3055465 | 0.82 | ALDH1A1 (0.70) | SMN1; SMN2LMNAMAPK1MAPTRAB9A | |
| SCHEMBL3053397 | 0.82 | KMT2A (0.60) | SMN1; SMN2LMNAMAPK1MAPTHPGD | |
| SCHEMBL24169389 | 0.81 | LMNA (0.71) | SMN1; SMN2LMNAMAPK1MAPTRAB9A | |
| SCHEMBL17899811 | 0.80 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAMAPK1MAPTRAB9A | |
| SCHEMBL3067918 | 0.79 | ALDH1A1 (0.60) | SMN1; SMN2LMNAMAPK1MAPTRAB9A | |
| SCHEMBL3065546 | 0.78 | MAPT (0.60) | SMN1; SMN2LMNAMAPK1MAPTRAB9A | |
| SCHEMBL3058436 | 0.78 | MAPT (0.58) | SMN1; SMN2LMNAMAPTRAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9199918-B2 | Small molecule inhibitors of AGBL2 | GEORGETOWN UNIVERSITY (US) | 2015-12-01 | — | — | US | disclosed |
| US-9199918-B2 | Small molecule inhibitors of AGBL2 | GEORGETOWN UNIVERSITY (US) | 2015-12-01 | — | — | US | disclosed |