Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | KLK7 | P49862 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | PKM | P14618 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24169389 | 0.82 | LMNA (0.71) | SMN1; SMN2MAPTRAB9ALMNAHPGD | |
| SCHEMBL17296947 | 0.80 | SMN1; SMN2 (0.72) | SMN1; SMN2MAPTRAB9ALMNAHPGD | |
| SCHEMBL22822561 | 0.79 | JAK2 (0.77) | SMN1; SMN2MAPTRAB9ALMNAHPGD | |
| SCHEMBL25760923 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTRAB9ALMNAHPGD | |
| SCHEMBL1901172 | 0.78 | ALDH1A1 (0.76) | SMN1; SMN2MAPTRAB9AALDH1A1TP53 | |
| SCHEMBL13219594 | 0.78 | RAB9A (0.70) | SMN1; SMN2MAPTRAB9ALMNAHPGD | |
| SCHEMBL7771326 | 0.78 | HPGD (0.73) | SMN1; SMN2MAPTRAB9ALMNAHPGD | |
| SCHEMBL16451213 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTRAB9ALMNAHPGD | |
| SCHEMBL17214835 | 0.76 | NQO2 (0.76) | SMN1; SMN2MAPTRAB9AHPGDALDH1A1 | |
| SCHEMBL17664665 | 0.76 | KLK7 (0.89) | SMN1; SMN2MAPTRAB9ALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9737546-B2 | Small molecules to enhance P53 activity | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-22 | — | — | US | disclosed |
| US-20160193214-A1 | SMALL MOLECULES TO ENHANCE P53 ACTIVITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160193214-A1 | SMALL MOLECULES TO ENHANCE P53 ACTIVITY | TP53, TP53BP1, MDM2 | SMN1; SMN2 4344/4885MAPT 2804/4885RAB9A 3348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.