Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18418878 | 0.80 | MAPT (0.44) | MAPTALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL18426690 | 0.73 | L3MBTL1 (0.43) | MAPTALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL18426688 | 0.73 | L3MBTL1 (0.43) | MAPTALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL2624375 | 0.73 | MAPT (0.44) | MAPTALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL2760410 | 0.70 | MAPT (0.47) | MAPTALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL12335522 | 0.70 | ALDH1A1 (0.47) | MAPTALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL8920036 | 0.70 | MAPT (0.47) | MAPTALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL30137920 | 0.70 | MAPT (0.51) | MAPTALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL24792528 | 0.69 | ALDH1A1 (0.41) | MAPTALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL16698871 | 0.68 | MAPT (0.46) | MAPTALDH1A1POLBL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150592-B1 | ALK KINASE INHIBITOR, AND PREPARATION METHOD AND USE THEREOF | SHANGHAI EMERALD WELLCARES PHARMACEUTICAL CO LTD (CN) | 2023-08-30 | — | — | EP | disclosed |
| CN-107540666-B | Benzofuran pyrazole amine protein kinase inhibitor | 杭州雷索药业有限公司 | 2023-03-24 | — | — | CN | disclosed |
| US-10710993-B2 | Benzofuran pyrazole amine kinase inhibitor | Hangzhou REX Pharmaceutical Co., LTD. (CN) | 2020-07-14 | — | — | US | disclosed |
| US-20190225600-A1 | BENZOFURAN PYRAZOLE AMINE KINASE INHIBITOR | Hangzhou REX Pharmaceutical Co., LTD. (CN) | 2019-07-25 | — | — | US | disclosed |
| EP-3476848-A1 | BENZOFURAN PYRAZOLE AMINE PROTEIN KINASE INHIBITOR | Hangzhou Rex Pharmaceutical Co., Ltd (CN) | 2019-05-01 | — | — | EP | disclosed |
| US-10023593-B2 | ALK kinase inhibitor, and preparation method and uses thereof | BEIJING PEARL BIOTECHNOLOGY LIMITED LIABILITY COMPANY (CN) | 2018-07-17 | — | — | US | disclosed |
| US-10023593-B2 | ALK kinase inhibitor, and preparation method and uses thereof | BEIJING PEARL BIOTECHNOLOGY LIMITED LIABILITY COMPANY (CN) | 2018-07-17 | — | — | US | disclosed |
| US-10023593-B2 | ALK kinase inhibitor, and preparation method and uses thereof | BEIJING PEARL BIOTECHNOLOGY LIMITED LIABILITY COMPANY (CN) | 2018-07-17 | — | — | US | disclosed |
| US-20170247392-A1 | ALK KINASE INHIBITOR, AND PREPARATION METHOD AND USES THEREOF | SHANGHAI EMERALD WELLCARES PHARMACEUTICAL CO., LTD (CN) | 2017-08-31 | — | — | US | disclosed |
| US-20170247392-A1 | ALK KINASE INHIBITOR, AND PREPARATION METHOD AND USES THEREOF | SHANGHAI EMERALD WELLCARES PHARMACEUTICAL CO., LTD (CN) | 2017-08-31 | — | — | US | disclosed |
| US-20170247392-A1 | ALK KINASE INHIBITOR, AND PREPARATION METHOD AND USES THEREOF | SHANGHAI EMERALD WELLCARES PHARMACEUTICAL CO., LTD (CN) | 2017-08-31 | — | — | US | disclosed |
| EP-3150592-A1 | ALK KINASE INHIBITOR, AND PREPARATION METHOD AND USE THEREOF | Beijing Pearl Biotechnology Limited Liability Company (CN) | 2017-04-05 | — | — | EP | disclosed |
| EP-3150592-A1 | ALK KINASE INHIBITOR, AND PREPARATION METHOD AND USE THEREOF | Beijing Pearl Biotechnology Limited Liability Company (CN) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015180685-A1 | ALK KINASE INHIBITOR, AND PREPARATION METHOD AND USE THEREOF | 北京浦润奥生物科技有限责任公司 | 2015-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247392-A1 | ALK KINASE INHIBITOR, AND PREPARATION METHOD AND USES THEREOF | ALK, BRAF, ABL1 | MAPT 2610/4885ALDH1A1 679/4885POLB 2723/4885 |
| US-10023593-B2 | ALK kinase inhibitor, and preparation method and uses thereof | ALK, BRAF, ABL1 | MAPT 2610/4885ALDH1A1 679/4885POLB 2723/4885 |
| US-10710993-B2 | Benzofuran pyrazole amine kinase inhibitor | ALK, MAP3K5, ARAF | MAPT 2121/4885ALDH1A1 1248/4885POLB 4082/4885 |
| US-20190225600-A1 | BENZOFURAN PYRAZOLE AMINE KINASE INHIBITOR | ALK, MAP3K5, ARAF | MAPT 2121/4885ALDH1A1 1248/4885POLB 4082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.