Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966179 | 0.79 | MAPT (0.41) | MAPTALDH1A1POLBL3MBTL1PKM | |
| SCHEMBL4561815 | 0.79 | NOS1 (0.49) | MAPTALDH1A1POLBL3MBTL1PKM | |
| SCHEMBL8920036 | 0.78 | MAPT (0.47) | MAPTALDH1A1POLBL3MBTL1MITF | |
| SCHEMBL12335522 | 0.78 | ALDH1A1 (0.47) | MAPTALDH1A1POLBL3MBTL1MITF | |
| SCHEMBL30137920 | 0.78 | MAPT (0.51) | MAPTALDH1A1POLBL3MBTL1MITF | |
| SCHEMBL7516830 | 0.78 | L3MBTL1 (0.40) | MAPTPOLBL3MBTL1MITFLMNA | |
| SCHEMBL14401140 | 0.77 | MAPT (0.46) | MAPTALDH1A1POLBL3MBTL1MITF | |
| SCHEMBL18418877 | 0.77 | MAPT (0.50) | MAPTALDH1A1POLBL3MBTL1MITF | |
| SCHEMBL2067197 | 0.77 | L3MBTL1 (0.47) | MAPTALDH1A1POLBL3MBTL1MITF | |
| SCHEMBL16698871 | 0.77 | MAPT (0.46) | MAPTALDH1A1POLBL3MBTL1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106674116-A | 4-amino-1,3-dimethyl pyrazol and compound method for pharmaceutical acceptable salt thereof | 苏州汉德创宏生化科技有限公司 | 2017-05-17 | — | — | CN | claimed |
| US-20240228493-A1 | LRRK2 INHIBITORS AND USES THEREOF | NEURON23, INC. | 2024-07-11 | — | — | US | disclosed |
| CN-116891437-A | Amino acid derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2023-10-17 | — | — | CN | disclosed |
| EP-4153570-A1 | AZETIDINE CYCLIC UREAS | Sironax Ltd. (KY) | 2023-03-29 | — | — | EP | disclosed |
| EP-4153582-A1 | PIPERAZINE CYCLIC UREAS | Sironax Ltd. (KY) | 2023-03-29 | — | — | EP | disclosed |
| CN-112654605-B | Bridged heterocyclic group substituted pyrimidine compound and preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2022-11-22 | — | — | CN | disclosed |
| US-20220348572-A1 | BRIDGED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | The National Institutes of Pharmaceutical R&D Co., Ltd. (CN) | 2022-11-03 | — | — | US | disclosed |
| CN-111484482-B | Alkynyl pyrimidine or alkynyl pyridine compound, and composition and application thereof | 北京赛特明强医药科技有限公司 | 2022-06-21 | — | — | CN | disclosed |
| EP-4011865-A1 | BRIDGED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | The National Institutes of Pharmaceutical R&D Co., Ltd (CN) | 2022-06-15 | — | — | EP | disclosed |
| CN-113912542-A | Method for directly ammoniating nitro nitrogen heterocyclic compound | 南京理工大学 | 2022-01-11 | — | — | CN | disclosed |
| US-6946462-B2 | N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2005-09-20 | — | — | US | disclosed |
| US-6869953-B2 | N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents | HOFFMAN-LA ROCHE INC. (US) | 2005-03-22 | — | — | US | disclosed |
| WO-2004043417-A2 | COMPOSITION FOR DYEING KERATIN FIBRES CONTAINING A DYE PRECURSOR AND AN ENZYME WITH NITROREDUCTASE ACTIVITY | L'OREAL (FR) | 2004-05-27 | — | — | WO | disclosed |
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |
| CN-1344255-A | Novel cationic oxidation bases, their use for dyeing keratin fibres, dyeing compsns. and dyeing methods | OREAL (FR) | 2002-04-10 | — | — | CN | disclosed |
| EP-0749433-A1 | (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY | ZENECA LIMITED (GB) | 1996-12-27 | — | — | EP | disclosed |
| US-5449682-A | Angiotensin II antagonists incorporating a substituted benzyl element | MERCK & CO., INC. (US) | 1995-09-12 | — | — | US | disclosed |
| US-5389660-A | Hypotensive agents | MERCK & CO., INC. (US) | 1995-02-14 | — | — | US | disclosed |
| US-5240938-A | Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring | MERCK & CO., INC. (US) | 1993-08-31 | — | — | US | disclosed |
| US-5164407-A | Hypotensive agents | MERCK & CO., INC. (US) | 1992-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220348572-A1 | BRIDGED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | TYK2, JAK1, JAK2 | MAPT 3395/4885ALDH1A1 2694/4885POLB 1999/4885 |
| US-20240228493-A1 | LRRK2 INHIBITORS AND USES THEREOF | LRRK2, PINK1, PARK7 | MAPT 151/4885ALDH1A1 4316/4885POLB 2356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.