Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17306342 | 0.99 | XDH (0.40) | XDHPDE5APDE1APDE1BPDE1C | |
| SCHEMBL19991494 | 0.97 | XDH (0.38) | XDHPDE5APDE1APDE1BPDE1C | |
| SCHEMBL1668005 | 0.90 | TBK1 (0.45) | TBK1IKBKE | |
| SCHEMBL17630321 | 0.89 | TBK1 (0.35) | TBK1IKBKEESR2 | |
| SCHEMBL17289926 | 0.89 | TBK1 (0.43) | XDHTBK1IKBKEESR2 | |
| SCHEMBL17630245 | 0.88 | TBK1 (0.37) | TBK1IKBKE | |
| SCHEMBL17631124 | 0.88 | TBK1 (0.34) | TBK1IKBKEESR2 | |
| SCHEMBL18340079 | 0.88 | TBK1 (0.43) | TBK1IKBKE | |
| SCHEMBL14976737 | 0.88 | TBK1 (0.38) | TBK1IKBKEESR2 | |
| SCHEMBL17289626 | 0.87 | TBK1 (0.41) | TBK1IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150344473-A1 | TANK-BINDING KINASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2015-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344473-A1 | TANK-BINDING KINASE INHIBITOR COMPOUNDS | TBKBP1, TNKS1BP1, TNKS | XDH 3680/4885PDE5A 4201/4885PDE1A 1957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.