Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.72 |
| ▸ | IDO1 | P14902 | 1/20 | 0.67 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.66 |
| ▸ | CLK3 | P49761 | 4/20 | 0.66 |
| ▸ | CLK2 | P49760 | 4/20 | 0.66 |
| ▸ | PIM1 | P11309 | 3/20 | 0.65 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.65 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.65 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.64 |
| ▸ | WNT1 | P04628 | 2/20 | 0.63 |
| ▸ | CDK7 | P50613 | 1/20 | 0.62 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | FER | P16591 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | MARK3 | P27448 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17306449 | 0.87 | MKNK1 (0.87) | MKNK1IDO1DYRK1ACLK2PIM1 | |
| SCHEMBL30588952 | 0.84 | JAK2 (0.69) | LRRK2DYRK1ACLK3CLK2PIM1 | |
| SCHEMBL29942349 | 0.84 | MAP2K4 (0.64) | MKNK1IDO1LRRK2DYRK1ACLK3 | |
| SCHEMBL10213963 | 0.84 | JAK2 (0.69) | LRRK2DYRK1ACLK3CLK2PIM1 | |
| SCHEMBL5508162 | 0.84 | MKNK1 (1.00) | MKNK1IDO1LRRK2DYRK1ACLK3 | |
| SCHEMBL760763 | 0.83 | DYRK1A (0.65) | MKNK1IDO1LRRK2DYRK1ACLK3 | |
| SCHEMBL18446560 | 0.83 | CLK3 (0.82) | IDO1LRRK2DYRK1ACLK3CLK2 | |
| SCHEMBL15869066 | 0.82 | WNT1 (0.73) | IDO1LRRK2DYRK1ACLK3CLK2 | |
| SCHEMBL30725847 | 0.80 | IDO1 (1.00) | IDO1LRRK2DYRK1ACLK3CLK2 | |
| SCHEMBL12318034 | 0.80 | IDO1 (1.00) | IDO1LRRK2DYRK1ACLK3CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7232912-B2 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | AGOURON PHARMACEUTICALS, INC. (US) | 2007-06-19 | — | — | US | disclosed |
| US-7232912-B2 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | AGOURON PHARMACEUTICALS, INC. (US) | 2007-06-19 | — | — | US | disclosed |
| US-7232912-B2 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | AGOURON PHARMACEUTICALS, INC. (US) | 2007-06-19 | — | — | US | disclosed |
| US-20060111322-A1 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | AGOURON PHARMACEUTICALS, INC. | 2006-05-25 | — | — | US | disclosed |
| US-20050239855-A1 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | AGOURON PHARMACEUTICALS, INC. | 2005-10-27 | — | — | US | disclosed |
| US-6919461-B2 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | AGOURON PHARMACEUTICALS, INC. (US) | 2005-07-19 | — | — | US | disclosed |
| US-20030139463-A1 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | REICH SIEGFRIED HEINZ (US) | 2003-07-24 | — | — | US | disclosed |
| US-6555539-B2 | For treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, psoriasis | AGOURON PHARMACEUTICALS | 2003-04-29 | — | — | US | disclosed |
| CN-1394205-A | Indazole compounds, pharmaceutical compositions, and their use for mediating or inhibiting cell proliferation | AGOURON PHARMA (US) | 2003-01-29 | — | — | CN | disclosed |
| US-20020161022-A1 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | AGOURON PHARMACEUTICALS | 2002-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239855-A1 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | CDK3, MKI67, ROCK1 | MKNK1 107/4885IDO1 27/4885LRRK2 1078/4885 |
| US-20020161022-A1 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | CDK3, MKI67, ROCK1 | MKNK1 107/4885IDO1 27/4885LRRK2 1078/4885 |
| US-20030139463-A1 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | CDK3, MKI67, ROCK1 | MKNK1 107/4885IDO1 27/4885LRRK2 1078/4885 |
| US-20060111322-A1 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | MKI67, CCNI, CDK3 | MKNK1 241/4885IDO1 21/4885LRRK2 2829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.