Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.51 |
| ▸ | WHR1 | P49842 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17307089 | 1.00 | MKNK1 (0.52) | MKNK1PIK3CAWHR1MEN1KMT2A | |
| SCHEMBL17307090 | 0.95 | PIK3CA (0.50) | MKNK1PIK3CAWHR1MEN1KMT2A | |
| SCHEMBL17307064 | 0.95 | PIK3CA (0.50) | MKNK1PIK3CAWHR1MEN1KMT2A | |
| SCHEMBL17307093 | 0.92 | KMT2A (0.53) | MKNK1PIK3CAWHR1MEN1KMT2A | |
| SCHEMBL17306756 | 0.92 | PIK3CA (0.51) | MKNK1PIK3CAWHR1MEN1KMT2A | |
| SCHEMBL17306757 | 0.90 | PIK3CA (0.46) | MKNK1PIK3CAWHR1MEN1KMT2A | |
| SCHEMBL17306446 | 0.90 | HPGD (0.53) | MKNK1PIK3CAWHR1MEN1KMT2A | |
| SCHEMBL17306587 | 0.90 | HPGD (0.53) | MKNK1PIK3CAWHR1MEN1KMT2A | |
| SCHEMBL17307036 | 0.90 | HPGD (0.53) | MKNK1PIK3CAWHR1MEN1KMT2A | |
| SCHEMBL24589764 | 0.89 | WHR1 (0.48) | MKNK1PIK3CAWHR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015182769-A1 | QUINAZOLINE AND BENZOQUINAZOLINE COMPOUNDS AND PRODUCTION AND USE OF SAME | 東ソー株式会社 | 2015-12-03 | — | — | WO | disclosed |