Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | WHR1 | P49842 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | GRK2 | P25098 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17307090 | 1.00 | PIK3CA (0.50) | PIK3CAMKNK1WHR1MEN1KMT2A | |
| SCHEMBL17307089 | 0.95 | MKNK1 (0.52) | PIK3CAMKNK1WHR1MEN1KMT2A | |
| SCHEMBL17306700 | 0.95 | MKNK1 (0.52) | PIK3CAMKNK1WHR1MEN1KMT2A | |
| SCHEMBL17307058 | 0.95 | WHR1 (0.47) | PIK3CAMKNK1WHR1MEN1KMT2A | |
| SCHEMBL17306757 | 0.90 | PIK3CA (0.46) | PIK3CAMKNK1WHR1MEN1KMT2A | |
| SCHEMBL17307061 | 0.89 | CYP1A2 (0.46) | PIK3CAWHR1MEN1KMT2AHPGD | |
| SCHEMBL17306432 | 0.88 | PIK3CA (0.47) | PIK3CAMKNK1WHR1MEN1KMT2A | |
| SCHEMBL17306710 | 0.88 | CYP1A2 (0.45) | PIK3CAWHR1MEN1KMT2AATM | |
| SCHEMBL17306686 | 0.88 | CYP1A2 (0.45) | PIK3CAWHR1MEN1KMT2AATM | |
| SCHEMBL17307055 | 0.88 | CYP1A2 (0.45) | PIK3CAWHR1MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015182769-A1 | QUINAZOLINE AND BENZOQUINAZOLINE COMPOUNDS AND PRODUCTION AND USE OF SAME | 東ソー株式会社 | 2015-12-03 | — | — | WO | disclosed |