Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | CA9 | Q16790 | 7/20 | 0.71 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.65 |
| ▸ | ITGAV | P06756 | 1/20 | 0.65 |
| ▸ | PPARA | Q07869 | 1/20 | 0.55 |
| ▸ | MGAM | O43451 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19481521 | 1.00 | FAAH (1.00) | FAAHLMNAHPGDSMN1; SMN2CA9 | |
| SCHEMBL19481507 | 0.84 | FAAH (0.73) | FAAHLMNAHPGDSMN1; SMN2CA9 | |
| SCHEMBL17295612 | 0.84 | LMNA (0.75) | FAAHLMNAHPGDSMN1; SMN2CA9 | |
| SCHEMBL17295616 | 0.84 | LMNA (0.75) | FAAHLMNAHPGDSMN1; SMN2CA9 | |
| SCHEMBL27861589 | 0.83 | FAAH (0.70) | FAAHLMNAHPGDSMN1; SMN2CA9 | |
| SCHEMBL11333427 | 0.82 | LMNA (0.72) | FAAHLMNAHPGDSMN1; SMN2CA9 | |
| SCHEMBL11333429 | 0.82 | LMNA (0.72) | FAAHLMNAHPGDSMN1; SMN2CA9 | |
| SCHEMBL28686336 | 0.81 | FAAH (0.68) | FAAHLMNAHPGDSMN1; SMN2CA9 | |
| SCHEMBL11329893 | 0.81 | CA9 (0.77) | FAAHLMNAHPGDSMN1; SMN2CA9 | |
| SCHEMBL11329898 | 0.81 | CA9 (0.77) | FAAHLMNAHPGDSMN1; SMN2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148541-B1 | THIAZOLIDINONES AS CELLULAR ANANDAMIDE UPTAKE INHIBITORS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | UNIV BERN (CH) | 2020-09-02 | — | — | EP | disclosed |
| EP-2952188-A1 | Thiazolidinones as cellular anandamide uptake inhibitors and their use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation | Universität Bern (CH) | 2015-12-09 | — | — | EP | disclosed |
| WO-2015181336-A1 | THIAZOLIDINONES AS CELLULAR ANANDAMIDE UPTAKE INHIBITORS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2015-12-03 | — | — | WO | disclosed |