Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 11/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | MEN1 | O00255 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17318518 | 0.80 | POLB (0.64) | POLBPTK2BNPSR1MAPTKMT2A | |
| SCHEMBL17318537 | 0.78 | POLB (1.00) | POLBPTK2BNPSR1MAPTKMT2A | |
| SCHEMBL13779379 | 0.77 | NPC1 (0.68) | POLBNPSR1MAPTKMT2AALDH1A1 | |
| SCHEMBL17712427 | 0.77 | KMT2A (0.71) | POLBNPSR1MAPTKMT2AALDH1A1 | |
| SCHEMBL31231560 | 0.73 | MAPT (0.85) | POLBPTK2BNPSR1MAPTKMT2A | |
| SCHEMBL17716806 | 0.73 | ALDH1A1 (0.49) | POLBPTK2BMAPTKMT2AALDH1A1 | |
| SCHEMBL16383876 | 0.72 | ALDH1A1 (0.68) | POLBPTK2BNPSR1MAPTKMT2A | |
| SCHEMBL12316774 | 0.72 | MEN1 (1.00) | POLBMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL7117863 | 0.71 | KDM4E (0.60) | POLBPTK2BNPSR1MAPTKMT2A | |
| SCHEMBL12443478 | 0.71 | KMT2A (0.72) | POLBMAPTKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015187827-A1 | NOVEL EFFECTIVE ANTIVIRAL COMPOUNDS AND METHODS USING SAME | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-12-10 | — | — | WO | disclosed |