Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 18/20 | 0.98 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1728751 | 0.99 | F2R (1.00) | F2RHTR1ADRD2DRD4HTR2A | |
| SCHEMBL14449152 | 0.93 | F2R (0.87) | F2R | |
| SCHEMBL13144389 | 0.92 | F2R (0.86) | F2R | |
| Bromide SCHEMBL1730235 | 0.92 | F2R (0.87) | F2R | |
| SCHEMBL13950221 | 0.92 | F2R (0.85) | F2R | |
| SCHEMBL1732773 | 0.91 | F2R (0.84) | F2R | |
| SCHEMBL13628887 | 0.91 | F2R (0.88) | F2R | |
| Atopaxar SCHEMBL30175034 | 0.91 | F2R (1.00) | F2R | |
| Atopaxar SCHEMBL1730339 | 0.91 | F2R (1.00) | F2R | |
| SCHEMBL1730944 | 0.90 | F2R (0.82) | F2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385039-B1 | 2-Iminoisoindolinone derivatives as thrombin receptor antagonists | EISAI R&D MAN CO LTD (JP) | 2014-03-12 | — | — | EP | claimed |
| EP-1391451-B1 | 2-IMINOPYRROLIDINE DERIVATES | EISAI R&D MAN CO LTD (JP) | 2011-11-23 | — | — | EP | claimed |
| EP-2385039-A1 | 2-Iminoisoindolinone derivatives as thrombin receptor antagonists | Eisai R&D Management Co., Ltd. (JP) | 2011-11-09 | — | — | EP | claimed |
| EP-1391456-B1 | 2-IMINOIMIDAZOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2009-07-22 | — | — | EP | claimed |
| EP-1386912-B1 | CYCLIC AMIDINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2009-03-18 | — | — | EP | claimed |
| US-20080139576-A1 | 5-Substituted 1,1-Dioxo- 1,2,5- Thiadiazolidin-3-One Derivatives | NOVARTIS AG (CH) | 2008-06-12 | — | — | US | claimed |
| US-7291635-B2 | 5-substituted 1,1-dioxo-1,2,5,-thiadiazolidin-3-one derivatives | NOVARTIS AG (CH) | 2007-11-06 | — | — | US | claimed |
| US-7244730-B2 | 2-iminopyrrolidine derivatives | EISAI CO., LTD (JP) | 2007-07-17 | — | — | US | claimed |
| US-20040023974-A1 | Cyclic sulfamide derivatives and methods of use | COPPOLA GARY MARK | 2004-02-05 | — | — | US | claimed |
| EP-2385039-B1 | 2-Iminoisoindolinone derivatives as thrombin receptor antagonists | EISAI R&D MAN CO LTD (JP) | 2014-03-12 | — | — | EP | disclosed |
| US-8658620-B2 | Pharmaceutical composition, use of 2-iminopyrrolidine derivative for production of pharmaceutical composition, and kit for treatment or amelioration of heart diseases | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-02-25 | — | — | US | disclosed |
| US-8658620-B2 | Pharmaceutical composition, use of 2-iminopyrrolidine derivative for production of pharmaceutical composition, and kit for treatment or amelioration of heart diseases | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-02-25 | — | — | US | disclosed |
| EP-1614680-B1 | Process for preparing 2-iminopyrrolidine derivatives | EISAI R&D MAN CO LTD (JP) | 2011-12-21 | — | — | EP | disclosed |
| EP-1492780-B1 | 5-SUBSTITUTED 1,1-DIOXO-¬1,2,5 THIAZOLIDINE-3-ONE DERIVATIVES AS PTPASE 1B INHIBITORS | NOVARTIS AG (CH) | 2011-11-23 | — | — | EP | disclosed |
| US-20070208016-A1 | Composition Containing Benzamidine Derivative and Method For Stabilizing Benzamidine Derivative | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-09-06 | — | — | US | disclosed |
| US-20070208016-A1 | Composition Containing Benzamidine Derivative and Method For Stabilizing Benzamidine Derivative | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-09-06 | — | — | US | disclosed |
| US-20070208016-A1 | Composition Containing Benzamidine Derivative and Method For Stabilizing Benzamidine Derivative | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-09-06 | — | — | US | disclosed |
| US-7244730-B2 | 2-iminopyrrolidine derivatives | EISAI CO., LTD (JP) | 2007-07-17 | — | — | US | disclosed |
| EP-1721610-A1 | COMPOSITION CONTAINING BENZAMIDINE DERIVATIVE AND METHOD FOR STABILIZING BENZAMIDINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2006-11-15 | — | — | EP | disclosed |
| US-20040023974-A1 | Cyclic sulfamide derivatives and methods of use | COPPOLA GARY MARK | 2004-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208016-A1 | Composition Containing Benzamidine Derivative and Method For Stabilizing Benzamidine Derivative | CMA1, DDC, GBA1 | F2R 4361/4885HTR1A 3247/4885DRD2 2216/4885 |
| US-20080139576-A1 | 5-Substituted 1,1-Dioxo- 1,2,5- Thiadiazolidin-3-One Derivatives | PTPRS, PTPRJ, IRS1 | F2R 1740/4885HTR1A 1028/4885DRD2 3149/4885 |
| US-20040023974-A1 | Cyclic sulfamide derivatives and methods of use | PTPRS, PTPA, PTPMT1 | F2R 1941/4885HTR1A 1363/4885DRD2 4743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.