Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 3/20 | 0.62 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.62 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.62 |
| ▸ | GSK3B | P49841 | 7/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.50 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.50 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.50 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | RBP4 | P02753 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18554248 | 0.88 | BCHE (0.56) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL929332 | 0.88 | PRKAG1 (0.79) | PRKAG1PRKAA1PRKAB1GSK3BROCK1 | |
| SCHEMBL28577811 | 0.86 | PRKAG1 (0.60) | PRKAG1PRKAA1PRKAB1GSK3BROCK1 | |
| SCHEMBL4794844 | 0.86 | KDM4E (0.63) | PRKAG1PRKAA1PRKAB1GSK3BROCK1 | |
| SCHEMBL17321404 | 0.84 | PRKAG1 (0.58) | PRKAG1PRKAA1PRKAB1GSK3BROCK1 | |
| SCHEMBL16099058 | 0.81 | PRKAG1 (0.55) | PRKAG1PRKAA1PRKAB1GSK3BROCK1 | |
| SCHEMBL493081 | 0.81 | KDM4E (0.64) | PRKAG1PRKAA1PRKAB1GSK3BKDM4E | |
| SCHEMBL31507475 | 0.81 | KDM4E (0.64) | PRKAG1PRKAA1PRKAB1GSK3BKDM4E | |
| SCHEMBL18967793 | 0.79 | MAP2K4 (0.54) | PRKAG1PRKAA1PRKAB1GSK3BFLT3 | |
| SCHEMBL13931888 | 0.78 | TUBB1 (0.57) | PRKAG1PRKAA1PRKAB1GSK3BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10385026-B2 | Phthalazinones and isoquinolinones as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-08-20 | — | — | US | disclosed |
| US-20180162823-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-06-14 | — | — | US | disclosed |
| US-20150353505-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353505-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | MYLK, MYLK2, ROCK1 | PRKAG1 570/4885PRKAA1 1032/4885PRKAB1 523/4885 |
| US-20180162823-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | MYLK, MYLK2, ROCK1 | PRKAG1 601/4885PRKAA1 1049/4885PRKAB1 532/4885 |
| US-10385026-B2 | Phthalazinones and isoquinolinones as rock inhibitors | MYLK, MYLK2, ROCK1 | PRKAG1 601/4885PRKAA1 1049/4885PRKAB1 532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.