Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.57 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.57 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | S100B | P04271 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17326282 | 0.90 | HPGD (0.68) | POLBKMT2AMAPK1MEN1HPGD | |
| SCHEMBL17326506 | 0.87 | MAPK1 (0.75) | POLBKMT2AMAPK1MEN1HPGD | |
| SCHEMBL17326730 | 0.81 | HPGD (0.62) | POLBKMT2AMAPK1MEN1HPGD | |
| SCHEMBL9458368 | 0.81 | HSD17B10 (0.76) | POLBKMT2AMAPK1MEN1HSD17B10 | |
| SCHEMBL20512991 | 0.80 | KMT2A (0.74) | POLBKMT2AMAPK1MEN1HPGD | |
| SCHEMBL17326722 | 0.80 | CYP2C9 (0.60) | POLBKMT2AMAPK1MEN1HPGD | |
| SCHEMBL9803534 | 0.79 | LPAR1 (0.77) | POLBKMT2AMAPK1MEN1HSD17B10 | |
| SCHEMBL6121212 | 0.77 | NR1H4 (0.62) | POLBKMT2AMAPK1HPGDHSD17B10 | |
| SCHEMBL11912138 | 0.76 | POLB (0.63) | POLBKMT2AMEN1HSD17B10LPAR1 | |
| SCHEMBL5159288 | 0.76 | MEN1 (0.60) | POLBKMT2AMAPK1MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015185785-A1 | DERIVATIVES OF ISOINDOLIN-1,3-DIONE | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (ES) | 2015-12-10 | — | — | WO | disclosed |