Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.50 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 3/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17326802 | 0.98 | RXRA (0.48) | RXRAPLA2G4APTPN11RARBRXRB | |
| SCHEMBL17326801 | 0.88 | RXRA (0.41) | RXRAPLA2G4AALDH1A1HPGDTP53 | |
| SCHEMBL17326622 | 0.88 | RXRA (0.51) | RXRARXRBRXRG | |
| SCHEMBL17326617 | 0.85 | RXRA (0.48) | RXRARXRBRXRG | |
| SCHEMBL17326599 | 0.79 | RXRA (0.52) | RXRAPTPN11RXRBRXRG | |
| SCHEMBL17326621 | 0.78 | RXRA (0.42) | RXRAALDH1A1HPGDRXRBRXRG | |
| SCHEMBL17326600 | 0.76 | RXRA (0.61) | RXRAPTPN11 | |
| SCHEMBL17326792 | 0.73 | KDM4E (0.43) | PLA2G4AALDH1A1HPGD | |
| SCHEMBL6840176 | 0.69 | RXRA (0.43) | RXRAPLA2G4AHPGDTSHR | |
| SCHEMBL16383665 | 0.69 | RXRA (0.43) | RXRAPLA2G4AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015187850-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF OCULAR DISORDERS | DUKE UNIVERSITY (US) | 2015-12-10 | — | — | WO | disclosed |