Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17326802 | 0.90 | RXRA (0.48) | RXRAPLA2G4ATP53TSHR | |
| SCHEMBL17326621 | 0.88 | RXRA (0.42) | RXRAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL17326601 | 0.88 | RXRA (0.50) | RXRAPLA2G4AALDH1A1HPGDTP53 | |
| SCHEMBL17326792 | 0.86 | KDM4E (0.43) | PLA2G4AKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL17326800 | 0.84 | KDM4E (0.41) | PLA2G4AKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL17326622 | 0.78 | RXRA (0.51) | RXRAROCK2PIM1PIM3 | |
| SCHEMBL17326803 | 0.77 | AR (0.39) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL17326620 | 0.76 | AR (0.38) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL17326617 | 0.75 | RXRA (0.48) | RXRAKDM4EPOLB | |
| SCHEMBL140918 | 0.72 | ROCK2 (0.47) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015187850-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF OCULAR DISORDERS | DUKE UNIVERSITY (US) | 2015-12-10 | — | — | WO | disclosed |