Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.51 |
| ▸ | RXRB | P28702 | 1/20 | 0.51 |
| ▸ | RXRG | P48443 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 2/20 | 0.39 |
| ▸ | MAX | P61244 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17326621 | 0.90 | RXRA (0.42) | RXRARXRBRXRGPPARGROCK2 | |
| SCHEMBL17326802 | 0.88 | RXRA (0.48) | RXRARXRBRXRG | |
| SCHEMBL17326601 | 0.88 | RXRA (0.50) | RXRARXRBRXRG | |
| SCHEMBL17326617 | 0.87 | RXRA (0.48) | RXRARXRBRXRGTYMSPTGER1 | |
| SCHEMBL25484510 | 0.80 | RXRA (0.68) | RXRARXRBRXRGPPARGMYC | |
| SCHEMBL17326569 | 0.78 | RXRA (0.50) | RXRARXRBRXRGPPARGEP300 | |
| SCHEMBL17326801 | 0.78 | RXRA (0.41) | RXRAROCK2PIM1PIM3 | |
| SCHEMBL17326803 | 0.76 | AR (0.39) | ROCK2PIM1PIM3 | |
| SCHEMBL17326555 | 0.75 | RXRA (0.47) | RXRARXRBRXRGPPARGPTGER1 | |
| SCHEMBL17326620 | 0.75 | AR (0.38) | ROCK2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015187850-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF OCULAR DISORDERS | DUKE UNIVERSITY (US) | 2015-12-10 | — | — | WO | disclosed |