Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30455625 | 0.82 | NOTUM (0.58) | TSHRMAPK1SMN1; SMN2KMT2ARAB9A | |
| SCHEMBL21097704 | 0.81 | GPR119 (0.51) | AKR1C3MAPK1SMN1; SMN2ADRB1MAPT | |
| SCHEMBL17322964 | 0.80 | ACACB (0.48) | MAPK1SMN1; SMN2MAPTLMNAKMT2A | |
| SCHEMBL17326796 | 0.80 | AKR1C3 (0.41) | AKR1C3TSHRMAPK1SMN1; SMN2ADRB1 | |
| SCHEMBL17326843 | 0.80 | NAMPT (0.49) | AKR1C3TSHRMAPK1SMN1; SMN2MAPT | |
| SCHEMBL1309976 | 0.77 | MAPT (0.42) | AKR1C3SMN1; SMN2ADRB1MAPTLMNA | |
| SCHEMBL17326793 | 0.76 | L3MBTL1 (0.42) | AKR1C3TSHRMAPK1SMN1; SMN2MAPT | |
| SCHEMBL20217190 | 0.75 | ADRB1 (0.47) | AKR1C3TSHRMAPK1SMN1; SMN2ADRB1 | |
| SCHEMBL25890156 | 0.75 | MAPT (0.40) | AKR1C3TSHRMAPK1SMN1; SMN2ADRB1 | |
| SCHEMBL19801268 | 0.75 | NOTUM (0.73) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150353495-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | ALEXION PHARMACEUTICALS, INC. | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353495-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | AKR1C3 1038/4885TSHR 3127/4885MAPK1 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.