Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18724248 | 0.93 | HRH3 (0.40) | ALDH1A1MEN1KMT2AHRH3MAPT | |
| SCHEMBL18724244 | 0.93 | HRH3 (0.40) | ALDH1A1MEN1KMT2AHRH3MAPT | |
| SCHEMBL19107799 | 0.88 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AHRH3SMN1; SMN2 | |
| SCHEMBL21007325 | 0.85 | CRHR1 (0.39) | ALDH1A1KMT2AHRH3MAPTCRHBP | |
| SCHEMBL19107789 | 0.83 | MAP4K4 (0.37) | ALDH1A1MEN1KMT2AHRH3BMPR1B | |
| SCHEMBL21301061 | 0.82 | MAPT (0.38) | ALDH1A1KMT2AHRH3MAPTCRHBP | |
| SCHEMBL19156485 | 0.82 | HRH3 (0.41) | ALDH1A1MEN1KMT2AHRH3MAPT | |
| SCHEMBL18723922 | 0.82 | HRH3 (0.39) | MEN1KMT2AHRH3MAPTCRHBP | |
| SCHEMBL18723920 | 0.82 | HRH3 (0.39) | MEN1KMT2AHRH3MAPTCRHBP | |
| SCHEMBL18724143 | 0.81 | KMT2A (0.41) | ALDH1A1MEN1KMT2AHRH3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49111-E1 | 2-acylaminothiazole derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2022-06-21 | — | — | US | disclosed |
| EP-3153511-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE FOR USE IN THE PREVENTION OR TREATMENT OF BLADDER/URINARY TRACT DISEASES | ASTELLAS PHARMA INC (JP) | 2019-05-15 | — | — | EP | disclosed |
| US-9951060-B2 | 2-acylaminothiazole derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2018-04-24 | — | — | US | disclosed |
| US-20170197955-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2017-07-13 | — | — | US | disclosed |
| EP-3153511-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2017-04-12 | — | — | EP | disclosed |
| WO-2015186821-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | アステラス製薬株式会社 | 2015-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197955-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | CHRM3, CHRM2, TRPM2 | ALDH1A1 1551/4885MEN1 4023/4885KMT2A 645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.