Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | KLK7 | P49862 | 2/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18886315 | 1.00 | LMNA (0.66) | LMNASMN1; SMN2IDO1L3MBTL1HTT | |
| SCHEMBL12196470 | 0.91 | SMN1; SMN2 (0.76) | LMNASMN1; SMN2IDO1L3MBTL1HTT | |
| SCHEMBL24383295 | 0.89 | LMNA (0.63) | LMNASMN1; SMN2IDO1L3MBTL1HTT | |
| SCHEMBL25330859 | 0.89 | LMNA (0.63) | LMNASMN1; SMN2IDO1L3MBTL1HTT | |
| SCHEMBL25195645 | 0.89 | LMNA (0.63) | LMNASMN1; SMN2IDO1L3MBTL1HTT | |
| SCHEMBL24572425 | 0.88 | SMN1; SMN2 (0.69) | LMNASMN1; SMN2IDO1L3MBTL1HTT | |
| SCHEMBL18886286 | 0.88 | SMN1; SMN2 (0.69) | LMNASMN1; SMN2IDO1L3MBTL1HTT | |
| SCHEMBL1668653 | 0.87 | SMN1; SMN2 (0.71) | LMNASMN1; SMN2IDO1L3MBTL1HTT | |
| SCHEMBL29467724 | 0.87 | LMNA (0.56) | LMNASMN1; SMN2IDO1L3MBTL1HTT | |
| SCHEMBL14768516 | 0.86 | LMNA (0.61) | LMNASMN1; SMN2IDO1L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9549988-B2 | Pharmaceutical compounds targeted by MIF affinity-tethered moieties | RJS Biologics (US) | 2017-01-24 | — | — | US | disclosed |
| US-20150352217-A1 | Pharmaceutical Compounds Targeted by MIF Affinity-Tethered Moieties | RJS BIOLOGICS LLC | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150352217-A1 | Pharmaceutical Compounds Targeted by MIF Affinity-Tethered Moieties | MIF, HMGB2, HMGB1 | LMNA 2800/4885SMN1; SMN2 3667/4885IDO1 234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.