Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13104263 | 0.79 | CNR2 (0.58) | PKMATMHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL14641240 | 0.77 | HSD17B10 (0.79) | PKMATMHSD17B10SMN1; SMN2HTT | |
| SCHEMBL30595308 | 0.77 | LMNA (0.49) | PKMATMHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL10737046 | 0.74 | PKM (0.41) | PKMATMHSD17B10CNR2 | |
| SCHEMBL4412024 | 0.73 | — | — | |
| SCHEMBL18839851 | 0.73 | PKM (0.47) | PKMATMHSD17B10LMNAHTT | |
| SCHEMBL18839891 | 0.73 | PKM (0.81) | PKMATMHSD17B10HTTCNR2 | |
| SCHEMBL4413215 | 0.70 | RECQL (0.42) | PKMATMHSD17B10LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3711535 | 0.69 | LTA4H (0.42) | PKMATMHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL13127229 | 0.69 | LTA4H (0.48) | PKMATMHSD17B10ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627631-B1 | PYRROLIDINONES AS METAP2 INHIBITORS | MERCK PATENT GMBH (DE) | 2015-12-16 | — | — | EP | claimed |