Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15419054 | 0.87 | SIRT2 (0.37) | ENPP2NR4A2CYP2C9ALDH1A3ALDH1A1 | |
| SCHEMBL1733052 | 0.83 | NR4A2 (0.47) | ENPP2NR4A2CYP2C9EGLN1 | |
| SCHEMBL1728545 | 0.80 | NR4A2 (0.47) | ENPP2NR4A2CYP2C9ALDH1A3ALDH1A1 | |
| SCHEMBL3770038 | 0.79 | KDM4E (0.49) | NR4A2CYP2C9ALDH1A1EGLN1 | |
| SCHEMBL3775596 | 0.78 | NR4A2 (0.66) | NR4A2CYP2C9EGLN1 | |
| SCHEMBL1733971 | 0.78 | NR4A2 (0.59) | NR4A2CYP2C9ALDH1A3ALDH1A1ALDH1A2 | |
| SCHEMBL1733982 | 0.73 | NR4A2 (0.48) | NR4A2CYP2C9EGLN1 | |
| SCHEMBL14496825 | 0.72 | ENPP2 (0.47) | ENPP2ALDH1A1 | |
| SCHEMBL1733303 | 0.72 | ALDH1A1 (0.38) | NR4A2CYP2C9ALDH1A3ALDH1A1ALDH1A2 | |
| SCHEMBL3825009 | 0.71 | ENPP2 (0.56) | ENPP2CYP2C9ALDH1A1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225240-B1 | Derivatives of 6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2014-01-22 | — | — | EP | claimed |
| EP-2225243-B1 | Derivatives of N-heterocyclic-6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2011-11-16 | — | — | EP | claimed |