Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.47 |
| ▸ | OGFRL1 | Q5TC84 | 5/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | CTSE | P14091 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17330665 | 1.00 | OPRM1 (0.47) | OPRM1OGFRL1OPRD1OPRK1PIK3CD | |
| SCHEMBL17330717 | 0.90 | PIK3CD (0.47) | OPRM1OGFRL1OPRD1PIK3CD | |
| SCHEMBL17330623 | 0.90 | PIK3CD (0.47) | OPRM1OGFRL1OPRD1PIK3CD | |
| SCHEMBL17330820 | 0.87 | OPRM1 (0.48) | OPRM1OGFRL1OPRD1OPRK1PIK3CD | |
| SCHEMBL17330563 | 0.85 | PIK3CD (0.44) | OPRM1OGFRL1OPRD1OPRK1PIK3CD | |
| SCHEMBL17330565 | 0.85 | PIK3CD (0.44) | OPRM1OGFRL1OPRD1OPRK1PIK3CD | |
| SCHEMBL17330951 | 0.85 | PIK3CD (0.44) | OPRM1OGFRL1OPRD1OPRK1PIK3CD | |
| SCHEMBL28833247 | 0.83 | PIK3CD (0.51) | PIK3CDTP53 | |
| SCHEMBL28833248 | 0.83 | PIK3CD (0.51) | PIK3CDTP53 | |
| SCHEMBL17338161 | 0.83 | PIK3CD (0.47) | OPRM1OGFRL1OPRD1OPRK1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154958-B1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2020-10-07 | — | — | EP | disclosed |
| US-10092563-B2 | Phosphatidylinositol 3-kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2018-10-09 | — | — | US | disclosed |
| US-20150361054-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2015-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150361054-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3CA, AKT3, PIK3CB | OPRM1 816/4885OGFRL1 2863/4885OPRD1 1959/4885 |
| US-10092563-B2 | Phosphatidylinositol 3-kinase inhibitors | PIK3CA, AKT3, PIK3CB | OPRM1 816/4885OGFRL1 2863/4885OPRD1 1959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.