Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | CTSE | P14091 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | LITAF | Q99732 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338223 | 0.90 | OPRM1 (0.44) | PIK3CDOPRM1OGFRL1OPRD1TP53 | |
| SCHEMBL17338184 | 0.86 | OPRM1 (0.44) | PIK3CDOPRM1OGFRL1OPRD1TP53 | |
| SCHEMBL17338395 | 0.85 | IL1B (0.43) | PIK3CDOPRM1OGFRL1OPRD1TP53 | |
| SCHEMBL17330665 | 0.83 | OPRM1 (0.47) | PIK3CDOPRM1OGFRL1OPRD1TP53 | |
| SCHEMBL17330662 | 0.83 | OPRM1 (0.47) | PIK3CDOPRM1OGFRL1OPRD1TP53 | |
| SCHEMBL17338273 | 0.81 | PDE10A (0.40) | PIK3CDOPRM1OGFRL1OPRD1OPRK1 | |
| SCHEMBL17338193 | 0.80 | BTK (0.44) | PIK3CDOPRM1OGFRL1OPRD1OPRK1 | |
| SCHEMBL4958732 | 0.76 | MAPT (0.50) | OPRM1OGFRL1OPRD1TP53OPRK1 | |
| SCHEMBL9955227 | 0.76 | OPRM1 (0.47) | OPRM1OGFRL1OPRD1OPRK1CTSD | |
| SCHEMBL4934581 | 0.75 | OPRM1 (0.57) | OPRM1OGFRL1OPRD1OPRK1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154958-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015191752-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-12-17 | — | — | WO | disclosed |