Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metamizole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.83 |
| ▸ | MAPT | P10636 | 1/20 | 0.83 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.83 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metamizole SCHEMBL1825291 | 0.92 | ALOX15 (0.97) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL24996 | 0.91 | ALOX15 (1.00) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL24995 | 0.90 | ALOX15 (0.97) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL28278546 | 0.89 | ALOX15 (0.95) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL934309 | 0.84 | ALOX15 (0.77) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL24997 | 0.81 | PTGS1 (1.00) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL27598082 | 0.79 | PTGS1 (0.97) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL27828487 | 0.79 | PTGS1 (0.97) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL867884 | 0.79 | PTGS1 (0.97) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL867882 | 0.78 | PTGS1 (0.95) | ALOX15KDM4EMAPTALOX12PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150359739-A1 | EDIBLE FILM-STRIPS FOR IMMEDIATE RELEASE OF ACTIVE INGREDIENTS | JOHNSON & JOHNSON CONSUMER INC (US) | 2015-12-17 | — | — | US | disclosed |