Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metamizole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.75 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | THRB | P10828 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 8/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metamizole SCHEMBL24995 | 0.99 | ALOX15 (0.97) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL1825291 | 0.99 | ALOX15 (0.97) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL28278546 | 0.97 | ALOX15 (0.95) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL17331306 | 0.91 | ALOX15 (0.83) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL934309 | 0.87 | ALOX15 (0.77) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL24997 | 0.86 | PTGS1 (1.00) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| SCHEMBL27870014 | 0.85 | PTGS1 (0.75) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL27598082 | 0.85 | PTGS1 (0.97) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL27828487 | 0.85 | PTGS1 (0.97) | ALOX15KDM4EMAPTALOX12PTGS1 | |
| Metamizole SCHEMBL867884 | 0.85 | PTGS1 (0.97) | ALOX15KDM4EMAPTALOX12PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 20160 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-116347432-B | Network authentication method, device, terminal and network side equipment | 中国移动通信有限公司研究院 | 2026-05-15 | — | — | CN | claimed |
| US-20260130928-A1 | COMBINATION OF AKR1C3 ACTIVATED ANTICANCER PRODRUG COMPOUND AND ANALGESIC DRUG FOR TREATING CANCER PATIENTS ACCOMPANIED BY PAIN | ASCENTAWITS PHARMACEUTICALS LTD (CN) | 2026-05-14 | — | — | US | claimed |
| EP-4734974-A1 | CANNABINOID COMPOSITION FOR USE IN THE TREATMENT OF PAIN AND/OR INFLAMMATION | Mabewo Phytopharm AG (CH) | 2026-05-06 | — | — | EP | claimed |
| US-20260115161-A1 | 2-HYDROXY-OCTADECENE-9-CIS-OATE FOR USE IN THE TREATMENT OF ONCOLOGICAL PATHOLOGIES AND NEUROPATHIC PAIN | LAMINAR PHARMACEUTICALS S A (ES) | 2026-04-30 | — | — | US | claimed |
| US-20260083666-A1 | METHOD OF TREATING DISEASE | CREWS THOMAS M (US) | 2026-03-26 | — | — | US | claimed |
| CN-121587036-A | Authentication method and device | OPPO广东移动通信有限公司 | 2026-02-27 | — | — | CN | claimed |
| EP-4663187-A1 | 2-HYDROXY-OCTADECENE-9-CIS-OATE FOR USE IN THE TREATMENT OF ONCOLOGICAL PATHOLOGIES AND NEUROPATHIC PAIN | Laminar Pharmaceuticals, S.A. (ES) | 2025-12-17 | — | — | EP | claimed |
| EP-3876493-B1 | AUTHENTICATION METHOD BASED ON GBA, AND DEVICE THEREOF | ZTE CORP (CN) | 2025-11-19 | — | — | EP | claimed |
| EP-4643556-A1 | A METHOD FOR PROVISIONING A USER EQUIPMENT WITH CREDENTIALS IN A PRIVATE TELECOMMUNICATION NETWORK | THALES (FR) | 2025-11-05 | — | — | EP | claimed |
| EP-0311616-A1 | COMBINATIONS OF GAMMA INTERFERONS AND ANTI-INFLAMMATORY OR ANTI-PYRETIC AGENTS FOR TREATING DISEASES. | BIOGEN NV (NL) | 1989-04-19 | — | — | EP | claimed |
| US-4816414-A | CONTROLLED FORMATION AND GROWTH OF OPTICALLY VISIBLE CRYSTALS | CRYSTAL DIAGNOSTICS, INC. (US) | 1989-03-28 | — | — | US | claimed |
| EP-0140886-B1 | FILM BADGE FOR DETERMINING CARBONYL COMPOUNDS | Crystal Diagnostic Systems, Inc. (US) | 1988-09-07 | — | — | EP | claimed |
| WO-1987007842-A1 | COMBINATIONS OF GAMMA INTERFERONS AND ANTI-INFLAMMATORY OR ANTI-PYRETIC AGENTS AND METHODS FOR TREATING DISEASES | BIOGEN N.V. (AN) | 1987-12-30 | — | — | WO | claimed |
| US-4711782-A | Prolonged release microcapsules and their production | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-12-08 | — | — | US | claimed |
| US-4699776-A | Suppositories containing analgesics, antipyretics or anti-inflammatory agents | R. P. SCHERER CORPORATION (US) | 1987-10-13 | — | — | US | claimed |
| EP-0140886-A4 | FILM BADGE FOR DETERMINING CARBONYL COMPOUNDS. | LITTLE INC A (US) | 1985-09-02 | — | — | EP | claimed |
| EP-0140886-A1 | FILM BADGE FOR DETERMINING CARBONYL COMPOUNDS. | LITTLE INC A (US) | 1985-05-15 | — | — | EP | claimed |
| WO-1984004165-A1 | FILM BADGE FOR DETERMINING CARBONYL COMPOUNDS | LITTLE INC A (US) | 1984-10-25 | — | — | WO | claimed |
| US-4380587-A | Film badge for determining carbonyl compounds | ARTHUR D. LITTLE, INC. (US) | 1983-04-19 | — | — | US | claimed |