Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467130 | 0.89 | HPGD (0.73) | KMT2AMEN1ALDH1A1HPGDLMNA | |
| SCHEMBL18134836 | 0.87 | CYP3A4 (0.65) | CYP3A4CYP2C19L3MBTL1KMT2AMEN1 | |
| SCHEMBL12992173 | 0.85 | CYP3A4 (0.68) | CYP3A4CYP2C19L3MBTL1ALDH1A1HPGD | |
| SCHEMBL660986 | 0.85 | KMT2A (0.62) | KMT2AMEN1ALDH1A1USP2HPGD | |
| SCHEMBL14679156 | 0.84 | TPSAB1 (0.62) | CYP3A4CYP2C19KMT2AMEN1ALDH1A1 | |
| SCHEMBL8269663 | 0.84 | HPGD (0.81) | CYP3A4CYP2C19L3MBTL1KMT2AMEN1 | |
| SCHEMBL4772495 | 0.84 | L3MBTL1 (0.61) | CYP3A4CYP2C19L3MBTL1KMT2AMEN1 | |
| SCHEMBL6824244 | 0.84 | CYP3A4 (0.66) | CYP3A4CYP2C19L3MBTL1KMT2AMEN1 | |
| SCHEMBL28313230 | 0.84 | HPGD (0.81) | CYP3A4CYP2C19L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL5326701 | 0.84 | HTT (0.70) | CYP2C19KMT2AMEN1ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015189433-A1 | PYRIDAZINONES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2015-12-17 | — | — | WO | disclosed |