Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.59 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | STK25 | O00506 | 1/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | MUSK | O15146 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065876 | 0.83 | FLT3 (0.58) | FLT3MAPK8MAPK10CTNNB1WNT3A | |
| SCHEMBL29336443 | 0.76 | FLT3 (0.54) | FLT3BMPR1BPLK4STK25CIT | |
| SCHEMBL1472881 | 0.74 | CTNNB1 (0.64) | FLT3MAP2K4CTNNB1WNT3AKDM4E | |
| SCHEMBL21855639 | 0.74 | FLT3 (0.65) | FLT3MAPK8MAPK10AHRKDM4E | |
| SCHEMBL3994500 | 0.73 | POLB (0.77) | KDM4EALDH1A1MAPTRAB9AMEN1 | |
| SCHEMBL6114106 | 0.72 | FLT3 (0.67) | FLT3MAPK8MAPK10AHRKDM4E | |
| Potassium Ion SCHEMBL2688939 | 0.72 | KDM4E (0.63) | FLT3CTNNB1WNT3AKDM4EYTHDC1 | |
| SCHEMBL1762971 | 0.72 | KDM4E (0.58) | FLT3CTNNB1WNT3AKDM4EYTHDC1 | |
| SCHEMBL6954648 | 0.72 | HTR1A (0.65) | KDM4EALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28477124 | 0.71 | ALDH1A1 (0.60) | FLT3AHRKDM4EYTHDC1STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943221-B1 | PIPERAZINE AMIDINES AS ANTIVIRAL AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2011-11-23 | — | — | EP | disclosed |
| EP-1943221-A1 | PIPERAZINE AMIDINES AS ANTIVIRAL AGENTS | Brystol-Myers Squibb Company (US) | 2008-07-16 | — | — | EP | disclosed |
| US-7396830-B2 | Piperazine amidines as antiviral agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-08 | — | — | US | disclosed |
| WO-2007041616-A1 | PIPERAZINE AMIDINES AS ANTIVIRAL AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20070078141-A1 | Piperazine amidines as antiviral agents | BRISTOL-MYERS SQUIBB COMPANY | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078141-A1 | Piperazine amidines as antiviral agents | IDO1, IDO2, EIF2AK2 | FLT3 2831/4885BMPR1B 4261/4885PLK4 831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.