Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.53 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338611 | 0.89 | GABRA1 (0.52) | GABRA1GABRB2GABRB1GABRA3MAPT | |
| SCHEMBL17338622 | 0.88 | GABRA1 (0.65) | GABRA1GABRB2GABRB1GABRA3MAPT | |
| SCHEMBL17338604 | 0.85 | GABRA1 (0.62) | GABRA1GABRB2GABRB1GABRA3POLB | |
| SCHEMBL17338620 | 0.85 | LMNA (0.61) | GABRA1GABRB2GABRB1GABRA3LMNA | |
| SCHEMBL17338615 | 0.85 | GABRA1 (0.61) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL17338628 | 0.83 | GABRA1 (0.53) | GABRA1GABRB2GABRB1GABRA3POLB | |
| SCHEMBL17338623 | 0.81 | GABRA1 (0.52) | GABRA1GABRB2GABRB1GABRA3LMNA | |
| SCHEMBL17338638 | 0.80 | POLB (0.50) | GABRA1GABRB2GABRB1GABRA3MAPT | |
| SCHEMBL17338542 | 0.80 | GABRA1 (0.64) | GABRA1GABRB2GABRB1GABRA3MAPT | |
| SCHEMBL17338645 | 0.79 | GABRA1 (0.79) | GABRA1GABRB2GABRB1GABRA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145914-A1 | AGENTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES STRUCTURALLY BASED ON 4(1 H)-QUINOLONE | UCL Business PLC (GB) | 2017-03-29 | — | — | EP | disclosed |
| WO-2015189560-A1 | AGENTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES STRUCTURALLY BASED ON 4(1 H)-QUINOLONE | UCL BUSINESS PLC (GB) | 2015-12-17 | — | — | WO | disclosed |