Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.62 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338616 | 0.88 | GABRA1 (0.63) | GABRA1GABRB2POLBGABRB1GABRA3 | |
| SCHEMBL17338622 | 0.86 | GABRA1 (0.65) | GABRA1GABRB2POLBGABRB1GABRA3 | |
| SCHEMBL17338596 | 0.85 | GABRA1 (0.53) | GABRA1GABRB2POLBGABRB1GABRA3 | |
| SCHEMBL17338620 | 0.83 | LMNA (0.61) | GABRA1GABRB2POLBGABRB1GABRA3 | |
| SCHEMBL396402 | 0.83 | GABRA1 (0.73) | GABRA1GABRB2POLBGABRB1GABRA3 | |
| SCHEMBL17338628 | 0.81 | GABRA1 (0.53) | GABRA1GABRB2POLBGABRB1GABRA3 | |
| SCHEMBL17338623 | 0.81 | GABRA1 (0.52) | GABRA1GABRB2POLBGABRB1GABRA3 | |
| SCHEMBL11948567 | 0.80 | GABRA1 (0.73) | GABRA1GABRB2POLBGABRB1GABRA3 | |
| SCHEMBL17338638 | 0.80 | POLB (0.50) | GABRA1GABRB2POLBGABRB1GABRA3 | |
| SCHEMBL17338647 | 0.79 | CFTR (0.66) | GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145914-A1 | AGENTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES STRUCTURALLY BASED ON 4(1 H)-QUINOLONE | UCL Business PLC (GB) | 2017-03-29 | — | — | EP | disclosed |
| WO-2015189560-A1 | AGENTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES STRUCTURALLY BASED ON 4(1 H)-QUINOLONE | UCL BUSINESS PLC (GB) | 2015-12-17 | — | — | WO | disclosed |