SCHEMBL17340511

SCHEMBL17340511

COC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c(Cl)c2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.63
GAA P10253 2/20 0.61
MAPT P10636 1/20 0.61
ALOX15 P16050 1/20 0.61
TSHR P16473 1/20 0.61
HTT P42858 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.61
LMNA P02545 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
TCF4 P15884 2/20 0.56
CTNNB1 P35222 2/20 0.56
KDM4E B2RXH2 1/20 0.56
PLAU P00749 2/20 0.55
HDAC3 O15379 1/20 0.54
HDAC4 P56524 1/20 0.54
HDAC1 Q13547 1/20 0.54
HDAC7 Q8WUI4 1/20 0.54
HDAC2 Q92769 1/20 0.54
HDAC10 Q969S8 1/20 0.54
HDAC11 Q96DB2 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25315174 0.85 MAPT (0.80) ALDH1A1GAAMAPTALOX15TSHR
SCHEMBL7579883 0.81 CYP19A1 (0.68) ALDH1A1GAAMAPTSMN1; SMN2LMNA
SCHEMBL5737651 0.80 ALDH1A1 (0.62) ALDH1A1GAAMAPTALOX15TSHR
SCHEMBL5925553 0.80 MAPT (0.72) ALDH1A1GAAMAPTALOX15TSHR
SCHEMBL1832364 0.80 MAPT (0.72) ALDH1A1GAAMAPTALOX15TSHR
SCHEMBL14408119 0.80 HDAC3 (0.59) ALDH1A1HDAC3HDAC4HDAC1HDAC7
SCHEMBL7571133 0.79 MAPT (0.63) ALDH1A1GAAMAPTHTTSMN1; SMN2
SCHEMBL7563643 0.79 CES1 (0.72) ALDH1A1GAAMAPTKMT2APOLB
SCHEMBL10361762 0.78 MAPT (0.65) ALDH1A1MAPTHTTLMNAHDAC3
SCHEMBL15772389 0.78 MAPT (0.70) ALDH1A1GAAMAPTALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2955173-A1 NOVEL 1,2-BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS ALLERGAN, INC. (US) 2015-12-16 EP disclosed