Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.68 |
| ▸ | PKM | P14618 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | PGR | P06401 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.58 |
| ▸ | PPIA | P62937 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PLAU | P00749 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5622490 | 0.88 | HPGD (0.72) | CYP19A1PKMHPGDLMNAGAA | |
| SCHEMBL790294 | 0.84 | GAA (0.86) | CYP19A1PKMLMNAGAAMAPK1 | |
| SCHEMBL7571133 | 0.83 | MAPT (0.63) | CYP19A1HPGDLMNAGAAMAPK1 | |
| SCHEMBL8752481 | 0.83 | PPIA (0.79) | CYP19A1PKMLMNAGAAMAPK1 | |
| SCHEMBL789993 | 0.83 | PPIA (0.79) | CYP19A1PKMLMNAGAAMAPK1 | |
| SCHEMBL7594141 | 0.83 | LMNA (0.67) | CYP19A1PKMLMNAGAAMAPK1 | |
| SCHEMBL7563643 | 0.82 | CES1 (0.72) | CYP19A1GAAALDH1A1MAPTMEN1 | |
| SCHEMBL10361762 | 0.82 | MAPT (0.65) | PKMLMNAALDH1A1PGRMAPT | |
| SCHEMBL29561510 | 0.82 | PGR (0.72) | CYP19A1PKMLMNAGAAMAPK1 | |
| SCHEMBL17340511 | 0.81 | ALDH1A1 (0.63) | LMNAGAAALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |