Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.35 |
| ▸ | DRD3 | P35462 | 9/20 | 0.35 |
| ▸ | DRD1 | P21728 | 7/20 | 0.35 |
| ▸ | DRD4 | P21917 | 7/20 | 0.35 |
| ▸ | DRD5 | P21918 | 7/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13726636 | 0.75 | GRM2 (0.51) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL18374895 | 0.70 | DRD2 (0.35) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL13824910 | 0.67 | LIPC (0.40) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL3476530 | 0.66 | GRM2 (0.48) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL13730358 | 0.64 | GRM2 (0.54) | — | |
| SCHEMBL2186985 | 0.63 | GRM2 (0.46) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL25027141 | 0.63 | DRD2 (0.38) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL15586261 | 0.62 | DRD2 (0.43) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL16580204 | 0.61 | DRD2 (0.40) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL18364503 | 0.61 | DRD2 (0.33) | DRD2DRD3DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2705024-B1 | Alkyne benzotriazole derivatives | MERCK SHARP & DOHME (US) | 2015-12-16 | — | — | EP | disclosed |