Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 5/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30274428 | 0.86 | EGLN1 (0.63) | VEGFAEGLN1HDAC1LMNACXCR4 | |
| SCHEMBL277774 | 0.86 | EGLN1 (0.63) | VEGFAEGLN1HDAC1LMNACXCR4 | |
| SCHEMBL17340661 | 0.73 | VEGFA (0.57) | VEGFAEGLN1CXCR4ALDH1A1 | |
| SCHEMBL17340697 | 0.73 | VEGFA (0.67) | VEGFAEGLN1HDAC1LMNAPOLB | |
| SCHEMBL17340662 | 0.71 | VEGFA (0.49) | VEGFAEGLN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL15314777 | 0.69 | CNR2 (0.42) | VEGFAEGLN1LMNAKDM4EALDH1A1 | |
| SCHEMBL21516685 | 0.69 | CXCR4 (0.48) | HDAC1LMNACXCR4POLBKDM4E | |
| SCHEMBL17340685 | 0.68 | EGLN1 (0.50) | VEGFAEGLN1ALDH1A1 | |
| SCHEMBL15314775 | 0.67 | KMT2A (0.47) | VEGFAEGLN1LMNAPOLBKDM4E | |
| SCHEMBL16603023 | 0.67 | CYP1A2 (0.40) | VEGFAEGLN1POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2952192-A1 | Prolyl hydroxylase inhibitors | Aerpio Therapeutics Inc. (US) | 2015-12-09 | — | — | EP | disclosed |
| EP-2649998-B1 | Prolyl hydroxylase inhibitors | AERPIO THERAPEUTICS INC (US) | 2015-03-04 | — | — | EP | disclosed |
| EP-2649998-A1 | Prolyl hydroxylase inhibitors | Aerpio Therapeutics Inc. (US) | 2013-10-16 | — | — | EP | disclosed |